IMTAKT multi-mode ODS Scherzo HPLC column

World's First Multi-Mode ODS Column

FEATURES

Capable of analyzing both anionic and cationic compounds simultaneously

Allows for ODS + ion-exchange separation

Utilizes three types of packing materials (SS-C18, SM-C18, SW-C18) based on ion-exchange strength

Enables retention and separation of highly polar compounds

Improves separation compared to general ODS columns

LC-MS compatible without the need for ion-pair reagents

This column addresses the challenge of retaining ionizable highly polar substances that were traditionally problematic with ODS columns, without requiring the addition of ion-pair reagents. Moreover, it facilitates separation of both anionic and cationic compounds in a single column.

Designed to maintain fundamental hydrophobicity similar to traditional ODS, it allows for analysis conditions to be evaluated in comparison with a reference column (Unison UK-C18).

Surface Structure and
Mobile Phase Design

General Usage of
Schero SM-C18 Column

Retention Characteristics
of Columns
(pH, Ionic Strength)

SS-C18 -suitable for weakly ionizable and zwitterionic compounds-

Cation (Positively Charged Ion)

Anion (Negatively Charged Ion)

Zwitterion (Amphoteric Ion)

Salts (Acids and Bases)

Chlorpheniramine MaleateMS

>>>See all Scherzo SS-C18 Application Database <<<

FEATURES

Surface Structure and Mobile Phase Design

General Usage of Schero SM-C18 Column

Retention Characteristics of Columns(pH, Ionic Strength)

SS-C18 -suitable for weakly ionizable and zwitterionic compounds-

Cation (Positively Charged Ion)

Anion (Negatively Charged Ion)

Zwitterion (Amphoteric Ion)

Salts (Acids and Bases)

>>>See all Scherzo SS-C18 Application Database <<<

SW-C18 - effective for highly ionized and high ion content compounds -

Cation (Positively Charged Ion)

Anion (Negatively Charged Ion)

Zwitterion (Amphoteric Ion)

Salts (Acids and Bases)

>>>See all Scherzo SW-C18 Application Database <<<

SM-C18 - maintains anionic and cationic compounds under neutral conditions -

Cation (Positively Charged Ion)

Anion (Negatively Charged Ion)

Zwitterion (Amphoteric Ion)

Salts (Acids and Bases)

>>>See all Scherzo SM-C18 Application Database <<<

Temporal trend and cross-sectional characterization of urinary concentrations of glyphosate in Japanese children from 2006 to 2015

SM-C18 MF

Genetic Landscape of Electron Transport Chain Complex I Dependency in Acute Myeloid Leukemia

SM-C18

2-Oxo-histidine-containing dipeptides are functional oxidation Products

SS-C18

Lipopolysaccharide-induced expansion of histidine decarboxylase-expressing Ly6G+ myeloid cells identified by exploiting histidine decarboxylase BAC-GFP transgenic mice

SM-C18

LC/MS-Based Polar Metabolite Profiling Identified Unique Biomarker Signatures for Cervical Cancer and Cervical Intraepithelial Neoplasia Using Global and Targeted Metabolomics

SM-C18

Maternal Vitamin C regulates reprogramming of DNA methylation and germline development

SM-C18

Comparative Genomics and Metabolomics Analyses of Clavulanic Acid-Producing Streptomyces Species Provides Insight Into Specialized Metabolism

SM-C18

Psychoactive plant- and mushroom-associated alkaloids from two behavior modifying cicada pathogens

SW-C18

Optical properties investigation of the reactions between methylglyoxal and glycine/ammonium sulfate

SM-C18

Defining Changes in the Spatial Distribution and Composition of Brain Lipids in the Shiverer and Cuprizone Mouse Models of Myelin Disease

SM-C18

Trimethylamine N-oxide and incident atherosclerotic events in high-risk individuals with diabetes: an ACCORD trial post hoc analysis

SM-C18

2-Methylacetoacetylcarnitine in blood of beta-ketothiolase deficiency and HSD10 disease

SS-C18

Investigation of relationship between sake-making parameters and sake metabolites using a newly developed sake metabolome analysis method

SM-C18

From Samples to Insights into Metabolism: Uncovering Biologically Relevant Information in LC-HRMS Metabolomics Data

SM-C18

Brain Delivery of Thyrotropin-Releasing Hormone via a Novel Prodrug Approach

SM-C18

Identification of glycyrrhizin metabolites in humans and of a potential biomarker of liquorice-induced pseudoaldosteronism: a multi-centre cross-sectional study

SM-C18

Simultaneous Determination of Etomidate and Its Major Metabolite, Etomidate Acid, in Urine Using Dilute and Shoot Liquid Chromatography-Tandem Mass Spectrometry

SM-C18

Effect of manufacturing temperature and storage duration on stability of chemically defined media measured with LC-MS/MS

SM-C18

18β-glycyrrhetyl-3-O-sulfate would be a causative agent of licorice-induced pseudoaldosteronism

SM-C18

Detection of Selenocyanate in Biological Samples by HPLC with Fluorescence Detection Using König Reaction

SS-C18

QuEChERS-Based Extraction Procedures for the Analysis of Bisphenols S and A in Breast Milk Samples by LC-QqQ-MS

SM-C18

Method Development for Selected Bisphenols Analysis in Sweetened Condensed Milk from a Can and Breast Milk Samples by HPLC-DAD and HPLC-QqQ-MS: Comparison of Sorbents (Z-SEP, Z-SEP Plus, PSA, C18, Chitin and EMR-Lipid) for Clean-Up of QuEChERS Extract

SM-C18

Psychoactive plant- and mushroom-associated alkaloids from two behavior modifying cicada pathogens

SW-C18

Characterization of Nicotine Salts in 23 Electronic Cigarette Refill Liquids

SM-C18

両イオン交換マルチモードODSカラムによるLC-MS/MSを用いた畜産食品中シロマジン分析法

SS-C18

Characterization of Mutations That Affect the Nonoxidative Pentose Phosphate Pathway in Sinorhizobium meliloti

SM-C18

Photoinduced Ligand Release from a Silicon Phthalocyanine Dye Conjugated with Monoclonal Antibodies: A Mechanism of Cancer Cell Cytotoxicity after Near-Infrared Photoimmunotherapy

SM-C18

Canagliflozin reduces plasma uremic toxins and alters the intestinal microbiota composition in a chronic kidney disease mouse model

SS-C18

Anti-allergic Effects of the Alkali Hydrolysis of Rapeseed Cake in a Rat Basophilic Leukemia Cell Line (RBL-2H3)

SM-C18

Surface Structure and
Mobile Phase Design

General Usage of
Schero SM-C18 Column

Retention Characteristics
of Columns
(pH, Ionic Strength)